Plasmodium falciparum gene encoding a protein similar to the 78-kDa rat glucose-regulated stress protein.

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Plasmodium falciparum gene encoding a protein similar to the 78-kDa rat glucose-regulated stress protein.

Genes homologous to heat shock protein 70 have been described in parasitic protozoa. It has been proposed that they may be important to the parasite as it moves from the vertebrate host at 37 degrees C to the insect. We now describe a genomic DNA clone isolated from Plasmodium falciparum that encodes a protein similar in sequence to a mammalian heat shock-related protein, the 78-kDa glucose-reg...

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A Plasmodium falciparum gene encoding a heat shock-like antigen related to the rat 78 Kd glucose-regulated protein.

We have cloned part of the genes encoding two antigens of 71 and 72 Kd froi P. falciparua (1,2). These polypeptides differ in their cellular location, expression during the parasite's erythrocytic cycle , isoeletric point in bi-dimensiona 1 gel electrophoresis and reaction with rabbit immune sera (1-3). The sequence of the 72 Kd gene identified it as a member of the P. falciparua heat-shock fam...

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therapeutic potential of glucose regulated protein 78 in cancer

endoplasmic reticulum has a critical role in the synthesis and folding of secretory and membrane proteins. high accumulation of proteins in er activates the unfolded protein response and glucose regulated protein 78 or gpr78 plays an essential role in this pathway.  unfolded protein response is activated in cancerous cells due to their adverse condition to survive and it has been shown that grp...

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Identification of highly conserved regulatory domains and protein-binding sites in the promoters of the rat and human genes encoding the stress-inducible 78-kilodalton glucose-regulated protein.

The gene encoding GRP78 has been shown to be constitutively expressed in many cell types and is inducible by the calcium ionophore A23187. To understand the regulation of GRP78 transcription, we analyzed the components that control its basal-level expression. By transfecting deletions into cells, we have identified a 54-nucleotide cis-acting regulatory element important for high basal-level exp...

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Overexpression of the 78-kDa glucose-regulated protein/immunoglobulin-binding protein (GRP78/BiP) inhibits tissue factor procoagulant activity.

Previous studies have demonstrated that overexpression of GRP78/BiP, an endoplasmic reticulum (ER)-resident molecular chaperone, in mammalian cells inhibits the secretion of specific coagulation factors. However, the effects of GRP78/BiP on activation of the coagulation cascade leading to thrombin generation are not known. In this study, we examined whether GRP78/BiP overexpression mediates cel...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 1988

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.85.17.6277